If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

BRI1_ARATH_863_1168

Protein BRASSINOSTEROID INSENSITIVE 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (BRI1_ARATH):D: Protein kinase (889:895, 897, 909, 911, 940, 956:959, 962, 963, 966, 1009, 1011, 1013, 1014, 1016, 1027)889:895, 897, 909, 911, 940, 956:959, 962, 963, 966, 1009, 1011, 1013, 1014, 1016, 1027

Full PDB list

4oh4, 4q5j, 5lpb, 5lpv, 5lpw, 5lpy, 5lpz (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
I
8
8
9
S
8
9
1
G
8
9
2
G
8
9
3
F
8
9
4
V
8
9
7
A
9
0
9
K
9
1
1
Y
9
5
6
E
9
5
7
F
9
5
8
M
9
5
9
S
9
6
3
D
9
6
6
D
1
0
0
9
K
1
0
1
1
S
1
0
1
3
N
1
0
1
4
L
1
0
1
6
D
1
0
2
7
[1]4oh4.b anp31 . . . . . . . . . . . . . . . . . . . .
[1]4q5j.a anp31 . . . . . . . . . . . * . . . . . . . .
[1]5lpb.a adp20 . . . . . . . . . . . . . . . . . . . .
[1]5lpv.a anp,mn32 . . . . . . . . . . . . . . . . . . . .
[1]5lpw.a none . . . . . . . . . . . . . . . . . . . .
[1]5lpy.a atp31 . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
I
8
8
9
G
8
9
0
S
8
9
1
G
8
9
2
G
8
9
3
F
8
9
4
G
8
9
5
V
8
9
7
A
9
0
9
K
9
1
1
V
9
4
0
Y
9
5
6
E
9
5
7
F
9
5
8
M
9
5
9
G
9
6
2
S
9
6
3
D
9
6
6
D
1
0
0
9
K
1
0
1
1
S
1
0
1
3
N
1
0
1
4
L
1
0
1
6
D
1
0
2
7
[1]4oh4.b . . . . . . . . . . . . . . . . . . . . . . . .
[1]4q5j.a . . . . . . . . . . . . . . * . . . . . . . . .
[1]5lpb.a . . . . . * . . . . . . . . . . . . . . . . . .
[1]5lpv.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]5lpw.a . . . . . . . . . . . . . . . . . . . . . . . .
[1]5lpy.a . . . . . * . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4oh4.b:anp
4q5j.a:anp
5lpb.a:adp
5lpv.a:anp,mn
5lpw.a is apo
5lpy.a:atp
[1] 4oh4.b
0.1
0.3 0.1 0.4 - 0.2
[1] 4q5j.a 0.1
0
0 0.3 - 0.1
[1] 5lpb.a 0.6 0.7
0
1.9 - 0.1
[1] 5lpv.a 0.1 0 0
0.2
- 0.2
[1] 5lpw.a 0.1 0.1 0.1 0.4
-
0.1
[1] 5lpy.a 0.3 0.2 0 1.4 -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4oh4.b
4q5j.a
5lpb.a
5lpv.a
5lpw.a
5lpy.a
[1] 4oh4.b
0
.02 .10 .02 .03 .08
[1] 4q5j.a .02
0
.09 0 .02 .07
[1] 5lpb.a .10 .09
0
.08 .07 .02
[1] 5lpv.a .02 0 .08
0
.03 .07
[1] 5lpw.a .03 .02 .07 .03
0
.06
[1] 5lpy.a .08 .07 .02 .07 .06
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.8 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4oh4.b
4q5j.a
5lpb.a
5lpv.a
5lpw.a
5lpy.a
[1] 4oh4.b
0
0.6 0.9 0.8 1.1 1.1
[1] 4q5j.a 0.6
0
0.8 0.7 0.9 0.9
[1] 5lpb.a 0.9 0.8
0
0.4 0.7 0.3
[1] 5lpv.a 0.8 0.7 0.4
0
0.6 0.5
[1] 5lpw.a 1.1 0.9 0.7 0.6
0
0.7
[1] 5lpy.a 1.1 0.9 0.3 0.5 0.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4oh4.b
4q5j.a
5lpb.a
5lpv.a
5lpw.a
5lpy.a
[1] 4oh4.b
0
1.0 1.6 0.9 1.1 1.7
[1] 4q5j.a 1.0
0
1.6 1.0 1.2 1.7
[1] 5lpb.a 1.6 1.6
0
0.4 0.7 0.5
[1] 5lpv.a 0.9 1.0 0.4
0
0.6 0.5
[1] 5lpw.a 1.1 1.2 0.7 0.6
0
0.7
[1] 5lpy.a 1.7 1.7 0.5 0.5 0.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...