BRD4_HUMAN_340_460

Bromodomain-containing protein 4

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (BRD4_HUMAN):D: Bromo 2 (374:376,380,384:387,429,432,433,437:439)
442
374:376,380,384:387,429,432,433,437:439,442

Full PDB list

2dww,2ouo,2yem,3jvl,3jvm,4kv4,4z93,5jwm (redundant pocketome entry)

Contact map

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ligand
A1
W
3
7
4
P
3
7
5
F
3
7
6
V
3
8
0
A
3
8
4
L
3
8
5
G
3
8
6
L
3
8
7
C
4
2
9
Y
4
3
2
N
4
3
3
H
4
3
7
E
4
3
8
V
4
3
9
M
4
4
2
[1]4z93.a 4ld 31 . . . . . . . . . . . . . . .
[1]2yem.a wsh 32 . . . . . . . . . . . . . . .
[1]2dww.a none . . . . . . . . . . . . . . *
[1]3jvl.a none . . . . . . . . . . . . . . .
[1]4kv4.a TFalySI 44 . . . . . . . . . . . . . . .
[1]5jwm.b 6on 77 . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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