If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

BMX_HUMAN_404_675

Cytoplasmic tyrosine-protein kinase BMX [Protein kinase superfamily. Tyr protein kinase family. TEC subfamily]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (BMX_HUMAN):D: Protein kinase (423:425, 431, 443:445, 464, 473, 487, 489:493, 495, 496, 543, 553, 555)423:425, 431, 443:445, 464, 473, 487, 489:493, 495, 496, 543, 553, 555

Full PDB list

3sxr, 3sxs

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
L
4
2
3
S
4
2
5
V
4
3
1
A
4
4
3
V
4
4
4
K
4
4
5
M
4
6
4
V
4
7
3
I
4
8
7
T
4
8
9
E
4
9
0
Y
4
9
1
I
4
9
2
S
4
9
3
G
4
9
5
C
4
9
6
L
5
4
3
S
5
5
3
F
5
5
5
[1]3sxr.a 1n133 . . . . . . . . . . . . . . . . . . .
[1]3sxs.a pp221 . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
L
4
2
3
G
4
2
4
S
4
2
5
V
4
3
1
A
4
4
3
V
4
4
4
K
4
4
5
M
4
6
4
V
4
7
3
I
4
8
7
T
4
8
9
E
4
9
0
Y
4
9
1
I
4
9
2
S
4
9
3
G
4
9
5
C
4
9
6
L
5
4
3
S
5
5
3
F
5
5
5
[1]3sxr.a . . . . . . . . . . . . . . . . . . . .
[1]3sxs.a . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
3sxr.a:1n1
3sxs.a:pp2
[1] 3sxr.a
0
0
[1] 3sxs.a 0.1
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
3sxr.a
3sxs.a
[1] 3sxr.a
0
.01
[1] 3sxs.a .01
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3sxr.a
3sxs.a
[1] 3sxr.a
0
0.7
[1] 3sxs.a 0.7
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.4 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
3sxr.a
3sxs.a
[1] 3sxr.a
0
0.8
[1] 3sxs.a 0.8
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...