BACE2_HUMAN_76_460

Beta-secretase 2 [Peptidase A1 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (BACE2_HUMAN):D: Peptidase A1 (92,108,110,112,113,148:151,185,186,188,193,196,273,301,303:307,310,406,409)
87:91
87:92,108,110,112,113,148:151,185,186,188,193,196,273,301,303:307,310,406,409

Full PDB list

2ewy,3zkg,3zki,3zkm,3zkn,3zkq,3zks,3zkx,3zl7,3zlq,4bel,4bfb (redundant pocketome entry)

Contact map

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ligand
A1
D
8
7
S
8
8
G
8
9
R
9
0
G
9
1
Y
9
2
L
1
0
8
D
1
1
0
G
1
1
2
S
1
1
3
K
1
4
8
Y
1
4
9
T
1
5
0
Q
1
5
1
N
1
8
5
F
1
8
6
L
1
8
8
W
1
9
3
I
1
9
6
Y
2
7
3
I
3
0
1
D
3
0
3
S
3
0
4
G
3
0
5
T
3
0
6
T
3
0
7
R
3
1
0
V
4
0
6
A
4
0
9
[1]3zlq.b 6t9 29 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2ewy.a dbo 38 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3zkm.b none . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3zkn.b wzv 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4bel.a b3p 19 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3zl7.a R 11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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