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ASIC1_CHICK_19_463

Acid-sensing ion channel 1 [Amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily]

Composition of the binding site

Protein chains monomer
A1 (ASIC1_CHICK):236:243, 342, 346, 347, 350, 354236:243, 342, 346, 347, 350, 354

Full PDB list

2qts, 3ij4, 3s3w, 3s3x, 4fz0, 4fz1, 4ntw, 4ntx, 4nty, 4nyk, 5wku, 5wkv (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
E
2
3
6
T
2
3
7
D
2
3
8
T
2
4
0
D
3
4
6
P
3
4
7
D
3
5
0
E
3
5
4
[1]2qts.d none . . . . . . . .
[1]4fz0.a RRRSF50 . . . . . . . .
[1]4ntx.a amr15 . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
E
2
3
6
T
2
3
7
D
2
3
8
E
2
3
9
T
2
4
0
S
2
4
1
F
2
4
2
E
2
4
3
K
3
4
2
D
3
4
6
P
3
4
7
D
3
5
0
E
3
5
4
[1]2qts.d . . . . . . . . . . . . .
[1]4fz0.a . . . . . . . . . . . . .
[1]4ntx.a . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2qts.d is apo
4fz0.a:RRRSF
4ntx.a:amr
[1] 2qts.d
-
0.1 0.3
[1] 4fz0.a -
0
0.1
[1] 4ntx.a - 0
0.1
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2qts.d
4fz0.a
4ntx.a
[1] 2qts.d
0
.04 .02
[1] 4fz0.a .04
0
.02
[1] 4ntx.a .02 .02
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2qts.d
4fz0.a
4ntx.a
[1] 2qts.d
0
0.4 0.3
[1] 4fz0.a 0.4
0
0.4
[1] 4ntx.a 0.3 0.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.3 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2qts.d
4fz0.a
4ntx.a
[1] 2qts.d
0
0.7 0.3
[1] 4fz0.a 0.7
0
0.7
[1] 4ntx.a 0.3 0.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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