If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

ARF1_HUMAN_12_181

ADP-ribosylation factor 1 [Small GTPase superfamily. Arf family]

Composition of the binding site

Protein chains monomer
A1 (ARF1_HUMAN):18, 51:53, 64:69, 74, 78, 81, 8218, 51:53, 64:69, 74, 78, 81, 82
Metals (Me):Mg

Full PDB list

1hur, 1r8q, 1r8s, 1re0, 1rrf, 1rrg, 1s9d, 3o47, 4c0a (redundant Pocketome entry); 1j2j, 1o3y, 2j59 (unprocessed)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 Me
M
1
8
F
5
1
V
5
3
T
6
4
W
6
6
D
6
7
W
7
8
Y
8
1
[1]1s9d.a afb20 . . . . . . . . Mg
[2]1r8s.a none . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 Me
M
1
8
F
5
1
N
5
2
V
5
3
T
6
4
V
6
5
W
6
6
D
6
7
V
6
8
G
6
9
I
7
4
W
7
8
Y
8
1
F
8
2
[1]1s9d.a . . . . . . . . . . . . . . Mg
[2]1r8s.a . . . . . . * . * . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
1s9d.a:afb
1r8s.a is apo
[1] 1s9d.a
0
-
[2] 1r8s.a 12
-
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (2 clusters)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
1s9d.a
1r8s.a
[1] 1s9d.a
0
.50
[2] 1r8s.a .50
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 1.9 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1s9d.a
1r8s.a
[1] 1s9d.a
0
2.5
[2] 1r8s.a 2.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 1.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
1s9d.a
1r8s.a
[1] 1s9d.a
0
3.9
[2] 1r8s.a 3.9
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...