ANM5_HUMAN_2_637

Protein arginine N-methyltransferase 5 [Class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ANM5_HUMAN):D: SAM-dependent MTase PRMT-type (308:312,319,323,324,326,327,333,435,437:439,444,503,577:580)
R: S-adenosyl-L-methionine binding (333)
R: Beta barrel (503,577:580)
300,304,307
300,304,307:312,319,323,324,326,327,333,435,437:439,444,503,577:580
Cofactors (cF):0xu/mta/sam/sfg

Full PDB list

4gqb,4x60,4x61,4x63,5c9z,5emj,5emk,5eml,5emm,5fa5 (redundant pocketome entry)

Contact map

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ligand
A1 cF
F
3
0
0
Y
3
0
4
Y
3
0
7
L
3
0
8
Q
3
0
9
S
3
1
0
P
3
1
1
L
3
1
2
L
3
1
9
T
3
2
3
Y
3
2
4
V
3
2
6
F
3
2
7
K
3
3
3
E
4
3
5
L
4
3
7
G
4
3
8
S
4
3
9
E
4
4
4
V
5
0
3
F
5
7
7
S
5
7
8
W
5
7
9
F
5
8
0
[1]5c9z.a 4z2 28 . . . . . . . . . . . . . . . . . . . . . . . . sfg
[1]5emk.a 5qh 29 . . . . . . . . . . . . . . . . . . . . . . . . sfg
[1]5emj.a 5qj 31 . . . . . . . . . . . . . . . . . . . . . . . . sfg
[1]5eml.a 5qk 29 . . . . . . . . . . . . . . . . . . . . . . . . sam
[1]5emm.a 5ql 30 . . . . . . . . . . . . . . . . . . . . . . . . sfg
[1]4x60.a 3xv 28 . . . . . . . . . . . . . . . . . . . . . . . . sfg
[1]4gqb.a aceSGRGKGGK 54 . . . . . . . . . . . . . . . . . . . . . . . . 0xu
[1]5fa5.a R 11 . . . . . . . . . . . . . . . . . . . . . . . . mta

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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