ANDR_HUMAN_666_919_allosteric

Androgen receptor [Nuclear hormone receptor family. NR3 subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains homodimer[show domain annotation]
 • A1 (ANDR_HUMAN):R: Interaction with LPXN (673,674,724:728,827,830,831,833:835,838,841)
R: Interaction with KAT7 (673,674)
R: Ligand-binding (724:728,827,830,831,833:835,838,841)
673,674,724:728,827,830,831,833:835,838,841
 • A2 (ANDR_HUMAN):R: Interaction with LPXN (879,880,883,884,886,887)
R: Ligand-binding (879,880,883,884,886,887)
879,880,883,884,886,887

Full PDB list

1e3g,1gs4,1i37,1i38,1t5z,1t63,1t65,1t73,1t74,1t76,1t79,1t7f,1t7m,1t7r,1t7t,1xj7,1xnn,1xow,1xq3,1z95,2am9,2ama,2amb,2ao6,2ax6,2ax7,2ax8,2ax9,2axa,2hvc,2ihq,2nw4,2oz7,2pio,2pip,2piq,2pit,2piu,2piv,2piw,2pix,2pkl,2pnu,2q7i,2q7j,2q7k,2q7l,2qpy,2yhd,2ylo,2ylp,2ylq,3b5r,3b65,3b66,3b67,3b68,3g0w,3rlj,3rll,3v49,3v4a,3zqt,4hlw,4k7a,4ogh,4oh5,4oha,4oil,4oiu,4oj9,4ojb,4ok1,4okb,4okt,4okw,4okx,4olm,4ql8,5cj6 (redundant pocketome entry); 2pir,2z4j,3l3x,3l3z,4oea,4oed,4oey,4oez,4ofr,4ofu (unprocessed)

Contact map

[download in TSV format]
   
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ligand
A1 A2
I
6
7
3
F
6
7
4
P
7
2
4
G
7
2
5
F
7
2
6
R
7
2
7
N
7
2
8
F
8
2
7
E
8
3
0
L
8
3
1
M
8
3
3
N
8
3
4
Y
8
3
5
E
8
3
8
R
8
4
1
F
8
7
9
D
8
8
0
I
8
8
3
K
8
8
4
H
8
8
6
M
8
8
7
[1]2pix.a flf 20 . . . . . . . . . . . . . . . . . . . . .
[1]2ylo.a ylo 29 . . . . . . . . . . . . . . . . . . . . .
[1]2ylq.a ylq 25 . . . . . . . . . . . . . . . . . . . . .
[1]2pip.l ico 12 . . . . . . . . . . . . . . . . . . . . .
[1]2piq.a none . . . . . . . . . . . . . . . . . . . . .
[1]3zqt.a 30z 22 . . . . . . . . . . . . . . . . . . . . .
[1]2ylp.a 056 20 . . . . . . . . . . . . . . . . . . . . .
[1]4hlw.a 17w 19 . . . . . . . . . . . . . . . . . . . . .
[1]2piw.a t3 23 . . . . . . . . . . . . . . . . . . . . .
[1]2qpy.a 4hy 21 . . . . . . . . . . . . . . . . . . . . .
[1]2pio.a 2mi 10 . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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