AMPN_PIG_63_963

Aminopeptidase N [Peptidase M1 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (AMPN_PIG):R: Metalloprotease (206,208,209,345:350,361,375,376,379,380,383,384,387,406,410,413,414,429,432:434,436,437,440,444,464,467,472,473,564,660,664,693,697,698)
R: Substrate binding (347:350)
206,208,209,345:350,361,375,376,379,380,383,384,387,406,410,413,414,429,432:434,436,437,440,444,464,467,472,473,564,660,664,693,697,698
Metals (Me):Zn

Full PDB list

4f5c,4fke,4fkh,4fkk,4hom,4naq,4nz8,4ou3 (redundant pocketome entry)

Contact map

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ligand
A1 Me
Q
2
0
6
Q
2
0
8
S
2
0
9
N
3
4
5
A
3
4
6
G
3
4
7
A
3
4
8
M
3
4
9
E
3
5
0
A
3
6
1
E
3
7
5
R
3
7
6
T
3
7
9
V
3
8
0
H
3
8
3
E
3
8
4
H
3
8
7
E
4
0
6
S
4
1
0
E
4
1
3
Y
4
1
4
L
4
2
9
P
4
3
2
G
4
3
3
D
4
3
4
Y
4
3
6
R
4
3
7
A
4
4
0
L
4
4
4
S
4
6
4
F
4
6
7
Y
4
7
2
S
4
7
3
L
5
6
4
Y
6
6
0
N
6
6
4
Q
6
9
3
S
6
9
7
S
6
9
8
[1]4fkk.a bes 22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4fke.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4fkh.a A 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4hom.a RPKPQQFFGLM 95 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4naq.a AAAAAAA 36 . . . . . . . . . . . . . . . Q . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4nz8.a A,AAAAAA 36 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4ou3.a CNGRCG 40 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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