AMPN_HUMAN_65_967

Aminopeptidase N [Peptidase M1 family]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (AMPN_HUMAN):R: Metalloprotease (211,213,214,351:355,363,381,385,388,389,392,411,442,469,472,477,864,894:897,900,903,904,907)
R: Interaction with HCoV-229E (351)
R: Substrate binding (352:355)
211,213,214,351:355,363,381,385,388,389,392,411,442,469,472,477,864,894:897,900,903,904,907
Metals (Me):Zn

Full PDB list

4fyq,4fyr,4fys,4fyt

Contact map

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ligand
A1 Me
Q
2
1
1
Q
2
1
3
A
2
1
4
A
3
5
1
G
3
5
2
A
3
5
3
M
3
5
4
E
3
5
5
R
3
6
3
R
3
8
1
V
3
8
5
H
3
8
8
E
3
8
9
H
3
9
2
E
4
1
1
R
4
4
2
S
4
6
9
F
4
7
2
Y
4
7
7
I
8
6
4
G
8
9
4
S
8
9
5
F
8
9
6
S
8
9
7
N
9
0
0
Q
9
0
3
A
9
0
4
R
9
0
7
[1]4fyr.a bes 22 . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn
[1]4fyq.a none . . . . . . . . . . . . . . . . . . . . - - - - . . . . Zn
[1]4fys.a VYIHPF 56 . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4fyt.a l2oVVD 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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