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ALF_PLAF7_1_369

Fructose-bisphosphate aldolase [Class I fructose-bisphosphate aldolase family]

Composition of the binding site

Protein chains monomer
A1 (ALF_PLAF7):38, 40:42, 45, 48, 49, 113, 152, 154, 197, 199, 237, 278:280, 309, 310, 313, 314, 31738, 40:42, 45, 48, 49, 113, 152, 154, 197, 199, 237, 278:280, 309, 310, 313, 314, 317

Full PDB list

1a5c, 2eph, 2pc4, 4tr9 (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
D
4
0
E
4
1
T
4
5
R
4
9
K
1
5
2
R
1
5
4
E
1
9
7
K
2
3
7
L
2
7
8
S
2
7
9
G
2
8
0
G
3
0
9
R
3
1
0
Q
3
1
3
A
3
1
4
L
3
1
7
[1]2eph.d DWN31 . . . . . . . . . . . . . . . .
[1]2pc4.b none . . . . . . . . . . . . . . . .
[1]4tr9.a 38d,DWN52 . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
A
3
8
D
4
0
E
4
1
S
4
2
T
4
5
K
4
8
R
4
9
K
1
1
3
K
1
5
2
R
1
5
4
E
1
9
7
L
1
9
9
K
2
3
7
L
2
7
8
S
2
7
9
G
2
8
0
G
3
0
9
R
3
1
0
Q
3
1
3
A
3
1
4
L
3
1
7
[1]2eph.d . . . . . . . . . . . . . . . . . . . . .
[1]2pc4.b . . . . . . . . * . . . . . . . . . . . .
[1]4tr9.a . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
2eph.d:DWN
2pc4.b is apo
4tr9.a:38d,DWN
[1] 2eph.d
0
- 0.9
[1] 2pc4.b 0.1
-
1.5
[1] 4tr9.a 0.7 -
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
2eph.d
2pc4.b
4tr9.a
[1] 2eph.d
0
.04 .07
[1] 2pc4.b .04
0
.10
[1] 4tr9.a .07 .10
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2eph.d
2pc4.b
4tr9.a
[1] 2eph.d
0
0.2 0.5
[1] 2pc4.b 0.2
0
0.4
[1] 4tr9.a 0.5 0.4
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.2 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
2eph.d
2pc4.b
4tr9.a
[1] 2eph.d
0
0.7 1.1
[1] 2pc4.b 0.7
0
0.9
[1] 4tr9.a 1.1 0.9
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

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