AKT2_HUMAN_145_478

RAC-beta serine/threonine-protein kinase [Protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (AKT2_HUMAN):D: Protein kinase (158:161,163:166,179,181,183,200,204,213,227,229:232,236,277,279,280,282,292:294)
R: Inhibitor binding (230:232)
R: Inhibitor binding (277,279)
R: Inhibitor binding (292,293)
158:161,163:166,179,181,183,200,204,213,227,229:232,236,277,279,280,282,292:294,439,443
Cofactors (cF):GRPRTTSFAE

Full PDB list

1gzk,1gzn,1gzo,1mrv,1mry,1o6k,1o6l,2jdo,2jdr,2uw9,2x39,2xh5,3d0e,3e87,3e88,3e8d (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1 cF
L
1
5
8
G
1
5
9
K
1
6
0
G
1
6
1
F
1
6
3
G
1
6
4
K
1
6
5
V
1
6
6
A
1
7
9
K
1
8
1
L
1
8
3
E
2
0
0
L
2
0
4
T
2
1
3
F
2
2
7
M
2
2
9
E
2
3
0
Y
2
3
1
A
2
3
2
E
2
3
6
K
2
7
7
E
2
7
9
N
2
8
0
M
2
8
2
T
2
9
2
D
2
9
3
F
2
9
4
F
4
3
9
F
4
4
3
[1]3d0e.a g93 31 . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3e87.a g95 26 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]2xh5.a x37 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]2x39.a x39 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]3e88.a g96 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]3e8d.a g98 34 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]2jdo.a i5s 28 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]2uw9.a gvp 24 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[1]2jdr.a l20 30 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE
[2]1gzk.a none . . . . . . . . . . . . . . . . . . . . . . . . . . . . -
[1]1o6k.a anp,mn,mn 33 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GRPRTTSFAE

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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