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AGTR2_HUMAN_35_335

Type-2 angiotensin II receptor [G-protein coupled receptor 1 family]

Composition of the binding site

Protein chains monomer
A1 (AGTR2_HUMAN):51, 93, 100, 103, 104, 108, 121, 124, 125, 128, 129, 174, 178, 182, 195, 197, 211, 214, 215, 269, 272, 304, 307, 30851, 93, 100, 103, 104, 108, 121, 124, 125, 128, 129, 174, 178, 182, 195, 197, 211, 214, 215, 269, 272, 304, 307, 308

Full PDB list

5unf, 5ung, 5unh (redundant Pocketome entry)

Pocket contact map

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PDB.ch
   
ligand
A1
Y
5
1
L
9
3
W
1
0
0
Y
1
0
3
Y
1
0
4
Y
1
0
8
G
1
2
1
L
1
2
4
T
1
2
5
M
1
2
8
F
1
2
9
T
1
7
8
R
1
8
2
C
1
9
5
M
1
9
7
I
2
1
1
M
2
1
4
K
2
1
5
W
2
6
9
F
2
7
2
I
3
0
4
G
3
0
7
F
3
0
8
[1]5unf.b 8es46 . . . . . . . . . . . . . . . . . . . . . . .
[1]5unh.a 8em47 . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

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PDB.ch
A1
Y
5
1
L
9
3
W
1
0
0
Y
1
0
3
Y
1
0
4
Y
1
0
8
G
1
2
1
L
1
2
4
T
1
2
5
M
1
2
8
F
1
2
9
S
1
7
4
T
1
7
8
R
1
8
2
C
1
9
5
M
1
9
7
I
2
1
1
M
2
1
4
K
2
1
5
W
2
6
9
F
2
7
2
I
3
0
4
G
3
0
7
F
3
0
8
[1]5unf.b . . . . . . . . . . . . . . . . . . . . . . . .
[1]5unh.a . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

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pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
5unf.b:8es
5unh.a:8em
[1] 5unf.b
0
0
[1] 5unh.a 0
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

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pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
5unf.b
5unh.a
[1] 5unf.b
0
0
[1] 5unh.a 0
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

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pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5unf.b
5unh.a
[1] 5unf.b
0
0.2
[1] 5unh.a 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
5unf.b
5unh.a
[1] 5unf.b
0
0.3
[1] 5unh.a 0.3
0
[Binding site full-atom RMSD matrix]







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[ENTRY 2D visualization]

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