AGO2_HUMAN_438_575

Protein argonaute-2 [Argonaute family. Ago subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (AGO2_HUMAN):D: Piwi (522,524:526,529,533,544:548,551,558,559,562,563,566,570,709,710,714,753,756,757,759:761,790,792,793,795,797,798,804,812,815)
R: Interaction with guide RNA (524:526,529,533,544:548,551,558,559,562,563,566)
358,365,369
358,365,369,522,524:526,529,533,544:548,551,558,559,562,563,566,570,709,710,714,753,756,757,759:761,790,792,793,795,797,798,804,812,815

Full PDB list

3luc,3lud,3lug,3luh,3luj,3luk,3qx8,3qx9,4f3t,4ola,4olb,4w5n,4w5o,4w5q,4w5r,4w5t,4z4c,4z4d,4z4e,4z4f,4z4g,4z4h,4z4i,5js1,5js2,5ki6 (redundant pocketome entry)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
D
3
5
8
I
3
6
5
A
3
6
9
L
5
2
2
G
5
2
4
K
5
2
5
T
5
2
6
Y
5
2
9
K
5
3
3
T
5
4
4
Q
5
4
5
C
5
4
6
V
5
4
7
Q
5
4
8
N
5
5
1
Q
5
5
8
T
5
5
9
N
5
6
2
L
5
6
3
K
5
6
6
K
5
7
0
K
7
0
9
R
7
1
0
R
7
1
4
H
7
5
3
I
7
5
6
Q
7
5
7
T
7
5
9
S
7
6
0
R
7
6
1
Y
7
9
0
R
7
9
2
C
7
9
3
R
7
9
5
V
7
9
7
S
7
9
8
Y
8
0
4
R
8
1
2
Y
8
1
5
[1]5js2.a 6op.f2t.6nw.uft.6oo.uft 130 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5ki6.a 6u0GGAGU 141 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3luh.a 5gp 5 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3lud.a amp 23 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3luc.a none - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3lug.a c5p 5 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3luj.a u5p 21 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3qx8.a gtg 29 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]3qx9.a atp 31 - - - . . . . . . . . . . . . . . . . . . - - - - - - - - - - - - - - - - - -
[1]4f3t.a UAAAGU 130 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4olb.a AAAAAA 133 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w5n.a UUCACAU 145 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w5r.a UUCACA 125 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4w5t.a UUCACAUU 165 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]5js1.a UUAUCU 123 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
Similar entries
Feedback