ADRB2_HUMAN_26_357_TM

Beta-2 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ADRB2_HUMAN):R: Agonist and antagonist binding (193,195,199,200,203,207)
R: Agonist and antagonist binding (286,289,290,293)
R: Agonist and antagonist binding (312,313,316)
90,93,99,109,110,113,114,117,118,191,192,308,309
90,93,99,109,110,113,114,117,118,191:193,195,199,200,203,207,286,289,290,293,308,309,312,313,316

Full PDB list

2r4r,2r4s,2rh1,3d4s,3kj6,3ny8,3ny9,3nya,3p0g,3pds,3sn6,4lde,4ldl,4ldo,4qkx,5d5a,5jqh (redundant pocketome entry); 5d6l (unprocessed)

Contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
G
9
0
H
9
3
W
9
9
W
1
0
9
T
1
1
0
D
1
1
3
V
1
1
4
V
1
1
7
T
1
1
8
C
1
9
1
D
1
9
2
F
1
9
3
T
1
9
5
Y
1
9
9
A
2
0
0
S
2
0
3
S
2
0
7
W
2
8
6
F
2
8
9
F
2
9
0
N
2
9
3
Y
3
0
8
I
3
0
9
N
3
1
2
W
3
1
3
Y
3
1
6
[1]3d4s.a tim 21 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4qkx.a 35v 26 . C . . . . . . . . . . . . . . . . . . . . . . . .
[1]3pds.a erc 31 . C . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ny9.a jsz 24 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ldl.a xqc 23 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3p0g.a p0g 27 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3ny8.a jrz 20 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]3nya.a jtz 18 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]4ldo.a ale 13 . . . . . . . . . . . . . . . . . . . . . . . . . .
[1]2r4r.a none . - - . . . . . . - - - - - - . . . . . - - - . . .
[1]5d5a.a cau 22 . . . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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