ADRB1_MELGA_31_367_TM

Beta-1 adrenergic receptor [G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ADRB1_MELGA):R: Agonist and antagonist binding (201,203,207,208,211,215)
R: Agonist and antagonist binding (303,306,307,310)
R: Agonist and antagonist binding (329,330,333)
101,102,117,118,121,122,125,199,200,325,326
101,102,117,118,121,122,125,199:201,203,207,208,211,215,303,306,307,310,325,326,329,330,333
Cofactors (cF):2cv/y01
Metals (Me):Na

Full PDB list

2vt4,2y00,2y01,2y02,2y03,2y04,2ycw,2ycx,2ycy,3zpq,3zpr,4ami,4amj,4bvn,4gpo,5a8e,5f8u (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1 cF Me
L
1
0
1
V
1
0
2
W
1
1
7
T
1
1
8
D
1
2
1
V
1
2
2
V
1
2
5
C
1
9
9
D
2
0
0
F
2
0
1
T
2
0
3
Y
2
0
7
A
2
0
8
S
2
1
1
S
2
1
5
W
3
0
3
F
3
0
6
F
3
0
7
N
3
1
0
F
3
2
5
V
3
2
6
N
3
2
9
W
3
3
0
Y
3
3
3
[1]2vt4.a p32 21 . . . . . . . . . . . . . . . . . . . . . . . . Na
[1]4amj.a cvd 30 . . . . . . . . . . . . . . . . . . . . . . . . 2cv Na
[1]4ami.b g90 27 . . . . . . . . . . . . . . . . . . . . . . . . 2cv
[1]2y02.a whj 27 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01 Na
[1]5a8e.a xtk 22 . . . . . . . . . . . . . . . . . . . . . . . . Na
[1]2y00.a y00 22 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01 Na
[1]3zpr.a 3wc 17 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01 Na
[1]2y03.b 5fw 15 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01
[1]2y04.b 68h 17 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01
[1]2ycw.a cau 22 . . . . . . . . . . . . . . . . . . . . . . . . 2cv Na
[1]3zpq.a xf5 15 . . . . . . . . . . . . . . . . . . . . . . . . 2cv,y01 Na
[1]4bvn.a p32 21 . . . . . . . . . . . . . . . . . . . . . . . . Na
[1]4gpo.a none . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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