ADHX_HUMAN_2_374

Alcohol dehydrogenase class-3 [Zinc-containing alcohol dehydrogenase family. Class-III subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains homodimer
 • A1 (ADHX_HUMAN):45,47,56:58,67,68,93,94,110,112,115,118,141,174,293,294,31845,47,56:58,67,68,93,94,110,112,115,118,141,174,293,294,318
 • A2 (ADHX_HUMAN):284,306,309,310284,306,309,310
Cofactors (cF):apr/nad
Metals (Me):Zn

Full PDB list

1m6h,1m6w,1ma0,1mc5,1mp0,1teh,2fze,2fzw,3qj5 (redundant pocketome entry)

Contact map

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ligand
A1 A2 cF Me
C
4
5
T
4
7
D
5
6
P
5
7
E
5
8
H
6
7
E
6
8
Y
9
3
I
9
4
L
1
1
0
Q
1
1
2
R
1
1
5
Q
1
1
8
M
1
4
1
C
1
7
4
G
2
9
3
V
2
9
4
A
3
1
8
K
2
8
4
F
3
0
6
V
3
0
9
T
3
1
0
[1]3qj5.a 022 31 . . . . . . . . . . . . . . . . . . . . . . nad Zn
[1]1mc5.a ahe 22 . . . . . . . . . . . . . . . . . . . . . . nad Zn
[1]1mc5.b zn 1 . . . . . . . . . . . . . . . . . . . . . . nad Zn
[1]1m6w.a 12h 15 . . . . . . . . . . . . . . . . . . . . . . Zn
[1]1ma0.a dao 14 . . . . . . . . . . . . . . . . . . . . . . nad Zn
[1]1ma0.b dao,zn 15 . . . . . . . . . . . . . . . . . . . . . . nad Zn
[1]2fze.a none . . . . . . . . . . . . . . . . . . . . . . apr Zn
[1]2fzw.a none . . . . . . L . . . . . . . . . . . . . . . nad Zn

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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