ACVR1_HUMAN_199_499

Activin receptor type-1 [Protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ACVR1_HUMAN):D: Protein kinase (212,214,215,219,222,233:235,248,263,281,283:287,289,290,293,340,341,343,353,354)212,214,215,219,222,233:235,248,263,281,283:287,289,290,293,340,341,343,353,354

Full PDB list

3h9r,3mtf,3oom,3q4u,4bgg,4c02,4dym (redundant pocketome entry)

Contact map

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ligand
A1
E
2
1
2
V
2
1
4
G
2
1
5
Y
2
1
9
V
2
2
2
A
2
3
3
V
2
3
4
K
2
3
5
E
2
4
8
L
2
6
3
L
2
8
1
T
2
8
3
H
2
8
4
Y
2
8
5
H
2
8
6
E
2
8
7
G
2
8
9
S
2
9
0
D
2
9
3
K
3
4
0
N
3
4
1
L
3
4
3
A
3
5
3
D
3
5
4
[1]4bgg.c 844 30 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3mtf.a a3f 26 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3oom.a 507 25 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3q4u.b ldn 31 . . . . . . . . . . . . . . . . . . . . . . . .
[1]4dym.a iyz 23 . . . . . . . . . . . . . . . . . . . . . . . .
[1]3h9r.a tak 30 . . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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