If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

ACCC_HAEIN_2_448

Biotin carboxylase

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (ACCC_HAEIN):D: Biotin carboxylation (9, 10, 82:84, 237, 238, 276, 290, 292, 294:296, 338, 382)
D: ATP-grasp (237, 238, 276, 290, 292, 294:296)
9, 10, 82:84, 237, 238, 276, 290, 292, 294:296, 338, 382
Cofactors (cF):acp/adp

Full PDB list

4mv1, 4mv3, 4mv4, 4mv6, 4mv7, 4mv8, 4mv9, 4rzq (redundant Pocketome entry)

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1 cF
N
9
R
1
0
Y
8
2
G
8
3
F
8
4
K
2
3
8
N
2
9
0
R
2
9
2
Q
2
9
4
V
2
9
5
E
2
9
6
R
3
3
8
D
3
8
2
[1]4mv3.a none . . . . . . . . . . . . . acp
[1]4mv6.a pct8 . . . . . . . . . . . . .
[1]4mv7.a ppf7 . . . . . . . . . . . . .
[1]4rzq.a y7y21 . . . . . . . . . . . . . adp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1 cF
N
9
R
1
0
Y
8
2
G
8
3
F
8
4
Q
2
3
7
K
2
3
8
E
2
7
6
N
2
9
0
R
2
9
2
Q
2
9
4
V
2
9
5
E
2
9
6
R
3
3
8
D
3
8
2
[1]4mv3.a . . . . . . . . . . . . . . . acp
[1]4mv6.a . . . . . . . . . . . . . . .
[1]4mv7.a . . . . . . . . . . . . . . .
[1]4rzq.a . . . . . . . . . . . . . . . adp

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4mv3.a is apo
4mv6.a:pct
4mv7.a:ppf
4rzq.a:y7y
[1] 4mv3.a
-
0.1 0.3 0.4
[1] 4mv6.a -
0
0.1 0.3
[1] 4mv7.a - 0.1
0
0.4
[1] 4rzq.a - 0 0.1
0.2
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4mv3.a
4mv6.a
4mv7.a
4rzq.a
[1] 4mv3.a
0
.01 .03 .02
[1] 4mv6.a .01
0
.02 .01
[1] 4mv7.a .03 .02
0
.03
[1] 4rzq.a .02 .01 .03
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.6 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4mv3.a
4mv6.a
4mv7.a
4rzq.a
[1] 4mv3.a
0
0.2 0.3 0.1
[1] 4mv6.a 0.2
0
0.2 0.1
[1] 4mv7.a 0.3 0.2
0
0.2
[1] 4rzq.a 0.1 0.1 0.2
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.1 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4mv3.a
4mv6.a
4mv7.a
4rzq.a
[1] 4mv3.a
0
0.6 0.7 0.7
[1] 4mv6.a 0.6
0
0.8 0.8
[1] 4mv7.a 0.7 0.8
0
0.5
[1] 4rzq.a 0.7 0.8 0.5
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...