ABL1_HUMAN_228_509_allosteric

Tyrosine-protein kinase ABL1 [Protein kinase superfamily. Tyr protein kinase family. ABL subfamily]

ActiveICM:

L C E

Composition of the binding pockets

Protein chains monomer[show domain annotation]
 • A1 (ABL1_HUMAN):D: Protein kinase (337,340,341,344,429,432,433,435,462:465,468,493)
502,506,510
337,340,341,344,429,432,433,435,462:465,468,493,502,506,510

Full PDB list

1fpu,1iep,1m52,1opj,1opk,1opl,2e2b,2f4j,2fo0,2g1t,2g2f,2g2h,2g2i,2gqg,2hiw,2hyy,2hz0,2hz4,2hzi,2hzn,2qoh,2v7a,2z60,3cs9,3dk3,3dk6,3dk7,3ik3,3k5v,3kf4,3kfa,3ms9,3mss,3oxz,3oy3,3pyy,3qri,3qrj,3qrk,3ue4,4twp,4wa9,4xey,4yc8,4zog,5hu9 (redundant pocketome entry)

Contact map

[download in TSV format]
   
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ligand
A1
A
3
3
7
L
3
4
0
L
3
4
1
A
3
4
4
L
4
2
9
I
4
3
2
A
4
3
3
Y
4
3
5
E
4
6
2
G
4
6
3
C
4
6
4
P
4
6
5
V
4
6
8
F
4
9
3
I
5
0
2
V
5
0
6
L
5
1
0
[1]3pyy.a 3yy 25 . . . . . . . . . . . . . . - - -
[1]3kf4.a none . . . . . . . . . . . . . . . . .
[2]3k5v.a stj 27 . . . . . . . . . . . . . . . . .
[1]3mss.b ms7 21 . . . . . . . . . . . . . . - - -
[2]1opk.a myr 16 . . . . . . . . . . . . . . . . .
[1]3ms9.a ms9 12 . . . . . . . . . . . . . . - - -
[1]4zog.b none . . . . . . . . . . . . . . . - -
[2]2fo0.a myr 15 . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)
[icb] Download ICM binary file
[xml] Download XML file
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