If you see this message after the page is completely loaded, then JavaScript is not supported or disabled in your browser. Please consider enabling JavaScript for this site.

AAK1_HUMAN_28_358

AP2-associated protein kinase 1 [Protein kinase superfamily. Ser/Thr protein kinase family]

Composition of the binding site

Protein chains monomer [domain annotation]
A1 (AAK1_HUMAN):D: Protein kinase (50, 52, 53, 60, 62, 72, 74, 94, 104, 126:133, 136, 180, 181, 183, 193, 194)50, 52, 53, 60, 62, 72, 74, 94, 104, 126:133, 136, 180, 181, 183, 193, 194

Full PDB list

4wsq, 5l4q, 5te0

Pocket contact map

[download in TSV format]
   
PDB.ch
   
ligand
A1
E
5
0
L
5
2
A
5
3
V
6
0
L
6
2
A
7
2
K
7
4
M
9
4
V
1
0
4
M
1
2
6
D
1
2
7
F
1
2
8
C
1
2
9
R
1
3
0
G
1
3
2
Q
1
3
3
N
1
3
6
E
1
8
0
N
1
8
1
L
1
8
3
C
1
9
3
D
1
9
4
[1]4wsq.a ksa35 . . . . . . . . . . . . . . . . . . . . . .
[1]5l4q.a lkb26 . . . . . . . . . . . . . . . . . . . . . .
[1]5te0.a xin40 . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Site contact map

[download in TSV format]
   
PDB.ch
A1
E
5
0
L
5
2
A
5
3
V
6
0
L
6
2
A
7
2
K
7
4
M
9
4
V
1
0
4
M
1
2
6
D
1
2
7
F
1
2
8
C
1
2
9
R
1
3
0
G
1
3
1
G
1
3
2
Q
1
3
3
N
1
3
6
E
1
8
0
N
1
8
1
L
1
8
3
C
1
9
3
D
1
9
4
[1]4wsq.a . . . . . . . . . . . . . . . . . . . . . . .
[1]5l4q.a . . . . . . . . . . . . . . . . . . . . . . .
[1]5te0.a . . . . . . . . . . . . . . . . . . . . . . .

Legend

B backbone contact  S side chain contact  F BB + SCh
.
 no contact C covalent bond
X X X X X  clash
X mutation to X * complex cases - deletion
M contact with cofactors/metals (if any)

Pocket-ligand steric compatibility

Ligands (x) vs pockets (y) colored by number of steric clashes

zoom: [−] [+]; [view as image]; [download as text]

pocketligand
≥10
9
8
7
6
5
4
3
2
1
0
4wsq.a:ksa
5l4q.a:lkb
5te0.a:xin
[1] 4wsq.a
0
0.1 1.0
[1] 5l4q.a 0.4
0
0.9
[1] 5te0.a 0.1 0.4
0
[Pocket-ligand steric clashes matrix]

Pocket clash dissimilarity (1 cluster)

Pockets (x) vs pockets (y) colored by ligand clash profile difference

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥1.
.9
.8
.7
.6
.5
.4
.3
.2
.1
.0
4wsq.a
5l4q.a
5te0.a
[1] 4wsq.a
0
.05 .06
[1] 5l4q.a .05
0
.06
[1] 5te0.a .06 .06
0
[Pocket clash dissimilarity matrix]

Site backbone RMSD (median 0.7 Å)

Pockets (x) vs pockets (y) colored by RMSD of site residue backbone atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4wsq.a
5l4q.a
5te0.a
[1] 4wsq.a
0
0.6 0.6
[1] 5l4q.a 0.6
0
0.5
[1] 5te0.a 0.6 0.5
0
[Binding site backbone RMSD matrix]

Site full-atom RMSD (median 0.5 Å)

Pockets (x) vs pockets (y) colored by RMSD of all site residue atoms

zoom: [−] [+]; [view as image]; [download as text]

pocketpocket
≥10 Å
9 Å
8 Å
7 Å
6 Å
5 Å
4 Å
3 Å
2 Å
1 Å
0 Å
4wsq.a
5l4q.a
5te0.a
[1] 4wsq.a
0
1.0 1.1
[1] 5l4q.a 1.0
0
0.7
[1] 5te0.a 1.1 0.7
0
[Binding site full-atom RMSD matrix]







[show 3D visualization]

[ENTRY 2D visualization]

L C X E | Background Color: | Anaglyph Stereo:

loading...